1/5/2024 0 Comments Robin macpherson journalyThese syntheses of such highly curved π systems by solution phase methods, starting from compounds that were derived from planar starting materials also by solution phase methods, demonstrate unequivocally that rational chemical syntheses of fullerenes, carbon nanotubes, and related carbon-rich molecules should all be possible using exclusively solution chemical methods! Recourse to high-temperature gas-phase pyrolysis should not be necessary. In agreement with theoretical predictions, the trigonal carbon atoms at the cores of these new hydrocarbons suffer even greater pyramidalization than that exhibited by the carbon atoms of C60 (average POAV angles = 12.6, 12.1, and 11.6° for 1, 2, and C60, respectively). These extended aromatic π systems constitute the largest curved subunits of C60 ever prepared. Short syntheses and X-ray crystal structures are reported for two new geodesic polyarenes, pentaindenocorannulene (1, C50H20) and tetraindenocorannulene (2, C44H18). These large effects illustrate the utility of bifunctional catalysis in an antibody active site for promoting reactions with unactivated substrates. The aspartate base in the Glu元4Ala variant provides an astonishing 109-fold rate advantage over the nonenzymatic reaction with acetate as base and exhibits an effective molarity of >106 M. Introduction of alanine at position 元4 unexpectedly boosts the activity of the catalyst substantially and broadens its pH optimum, perhaps because ordered water molecules are able to assume the role of proton donor over a wider range of conditions than the original glutamic acid. HisH95 appears to activate the base, whereas Glu元4 may stabilize the incipient phenolate anion in the transition state at acidic pH. Site-directed mutagenesis and subsequent kinetic analysis identified AspH35 as the likely catalytic base that initiates proton abstraction. Thus, the side chains of three polar residues, AspH35, HisH95, and Glu元4, project into an otherwise hydrophobic cavity. It shows that the 2-aminobenzimidazolium derivative originally used for immunization was successful in templating an active site containing multiple functional groups. This foreign-language journaling platform where you can write in your target language(s) and get feedback from native or advanced speakers has already blossomed into a warm and encouraging community that has helped almost 10,000 language learners improve their skills and make meaningful connections with other journalers around the world.Īs I continue forward in life, I hope to continue improving my filmmaking skills and working on more short documentaries as well as my first feature-length documentary films, along with continuing to build delightful software, take beautiful photographs, and just continue having the most positive impact I can.ĭon't be shy and say hello if you’d like to chat about opportunities :) say hello.The structure of antibody 13G5, which catalyzes the conversion of unactivated benzisoxazoles to the corresponding salicylonitriles, was determined at 2.65 Å resolution in the absence of ligand. I'm a passionate software engineer and the founder of Journaly, where I have led design and engineering for the past four years, along with my amazing core-team member and friend, Ryan. I hope you like my little shopwhere I plan to add all kinds of delightful things over time :) I love to design & build delightful product experiences along with the unique challenges and nuances that come with each one. I've started work on a second book that I CAN'T WAIT to finish, taking everything I learned from both writing and designing my first one to make an even more beautiful book packed with tons more content and value. I also designed & wrote a book all about How To Maintain Languages. I create many types of videos over on my YouTube channel ranging from tips, methods & tutorials, musings, interviews, and – my favourite – short documentaries ❤️ I also frequently share thoughtful photos over on Instagram. I speak nine languages and adore creating all kinds of content about language learning.
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